Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans.

OBJECTIVE To study the association of vaspin with glucose metabolism. DESIGN Cross-sectional and intervention study. SUBJECTS AND METHODS The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic-hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally...

Circulating vaspin is unrelated to insulin sensitivity in a cohort of non-diabetic humans Short running title: serum vaspin and insulin sensitivity

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

OBJECTIVE We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts insulin sensitivity in humans. RESEARCH DESIGN AND METHODS The fasting fatty acid pattern in the plasma free fatty acid (FFA) fraction was determined in 100 subjects at increased risk for type 2 diabetes. Insulin sensitivity was estimated during an oral glucose tolerance test (OGTT) at baseline...

Insulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans

It has been hypothesized that insulin might mediate meal-related diurnal variation in vaspin serum concentrations. We therefore investigated whether insulin affects serum vaspin levels in humans. Vaspin serum concentrations were determined by ELISA in 10 healthy individuals, who underwent an insulin tolerance test (ITT) for the evaluation of pituitary ACTH and growth hormone reserve. The ITTs w...

Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women.

To evaluate mechanisms underlying the close association between insulin secretion and insulin sensitivity, insulin sensitivity was evaluated by the euglycemic-hyperinsulinemic clamp technique (M/I(clamp)) and insulin secretion was determined from the 75-g oral glucose tolerance test (OGTT) and from the glucose-dependent arginine-stimulation test in 81 nondiabetic postmenopausal women, all aged ...